cenobamate will lessen the extent or impact of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Enhance dose of CYP3A4 substrate, as necessary, when coadministered with cenobamate.fentanyl transdermal and imipramine both improve sedation. Prevent or Use Alternate Drug. Limit use t